General practice & primary care · UKMLA & AKT
Benign prostatic hyperplasia
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Non-malignant enlargement of the prostate due to cellular proliferation (true hyperplasia, not hypertrophy) in the transition zone
- Affects ~40% of men in their 50s, up to ~90% by their 90s
- DHT (converted from testosterone by 5-alpha reductase) drives prostatic cell proliferation - explains mechanism of drug therapy
BPH arises in the transition zone (causing BOO/LUTS); prostate cancer arises in the peripheral zone (hard, irregular DRE; may have no LUTS early).
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