General practice & prim · UKMLA & AKT
Benign prostatic hyperplasia
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise benign prostatic hyperplasia — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Non-malignant enlargement of the prostate due to cellular proliferation (true hyperplasia, not hypertrophy) in the transition zone
- Affects ~40% of men in their 50s, up to ~90% by their 90s
- DHT (converted from testosterone by 5-alpha reductase) drives prostatic cell proliferation - explains mechanism of drug therapy
BPH arises in the transition zone (causing BOO/LUTS); prostate cancer arises in the peripheral zone (hard, irregular DRE; may have no LUTS early).
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