Renal & urology · UKMLA & AKT
Membranous nephropathy
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Most common cause of nephrotic syndrome in adults over 50 in the UK (~25% of adult nephrotic syndrome cases)
- More common in men; peak incidence fifth and sixth decades for primary disease
- Primary (idiopathic) cause: IgG antibodies against PLA2R (phospholipase A2 receptor) on podocytes - forms subepithelial immune complexes → complement activation via MAC → podocyte injury
- Carries the highest thromboembolic risk of all nephrotic glomerulonephritides
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