Ear, nose & throat · UKMLA & AKT
Nasopharyngeal carcinoma
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Malignancy arising from the epithelial lining of the nasopharynx - most commonly the fossa of Rosenmuller
- Dramatically higher incidence in Southern China, South-East Asia, North Africa - heightened suspicion in patients of East/South-East Asian heritage
- EBV is the central aetiological factor - drives non-keratinising NPC (the dominant subtype worldwide)
EBV drives NPC; HPV drives oropharyngeal SCC (tonsillar, base of tongue). These are not interchangeable. Asian ethnicity + posterior triangle node + SCC = NPC = EBV.
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