Cardiovascular · UKMLA & AKT

Stroke (ischaemic)

A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise stroke (ischaemic) — the full SA Note notes add investigations, management, complications and 10 practice questions.

Key high-yield points

  • First-line: clopidogrel - NICE first-line antiplatelet for secondary prevention after ischaemic stroke; inhibits ADP-mediated platelet activation
  • If clopidogrel contraindicated or not tolerated: aspirin + dipyridamole combination
  • If AF confirmed as cause: anticoagulation with a DOAC (e.g. apixaban) replaces antiplatelet therapy entirely - start at ~14 days to reduce risk of haemorrhagic transformation

Clopidogrel is NICE first-line for secondary prevention - not aspirin alone, not aspirin + dipyridamole. Aspirin 300 mg is used acutely (first 24 h post-thrombolysis) but is not the long-term secondary prevention agent of choice.

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Related UKMLA topics

Acute mesenteric ischaemiaRenal artery thrombosis/embolismCardiac tamponadeOrthostatic/ postural hypotensionVenous insufficiency (including varicose veins)Cardiac arrest