Acute & emergency · UKMLA & AKT
Acute haemolytic transfusion reaction
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise acute haemolytic transfusion reaction — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Caused by ABO-incompatible blood - almost always human error (mislabelled sample, failed identity check)
- Preformed IgM anti-ABO antibodies → classical complement activation → intravascular haemolysis + macrophage cytokine release → fever, pain, shock
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