Endocrine & metabolic · UKMLA & AKT
Diabetic microvascular complications
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Sustained hyperglycaemia → polyol pathway excess, AGE formation, PKC activation, oxidative stress → endothelial and pericyte damage → leaky, ischaemic small vessels
- Glucose enters endothelial cells independently of insulin - they are directly exposed to plasma glucose levels
- Hypertension accelerates injury in all three compartments - BP control is as important as glucose control
Unlock the full Diabetic microvascular complications revision
Get the complete high-yield notes (5 more sections covering investigations, management and complications), practice questions, mock exams and Sal, the AI tutor. Start free.