Gastroenterology · UKMLA & AKT

Pancreatic exocrine insufficiency

A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.

Key high-yield points

  • Lipase is most clinically critical - irreversibly inactivated at low pH, no salivary/gastric backup - fat malabsorption dominates
  • >90% of exocrine capacity must be lost before steatorrhoea appears - explains late presentation in chronic pancreatitis (typically 10-15 years into disease)

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