Gastroenterology · UKMLA & AKT
Pancreatic exocrine insufficiency
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise pancreatic exocrine insufficiency — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Lipase is most clinically critical - irreversibly inactivated at low pH, no salivary/gastric backup - fat malabsorption dominates
- >90% of exocrine capacity must be lost before steatorrhoea appears - explains late presentation in chronic pancreatitis (typically 10-15 years into disease)
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