Gastroenterology · UKMLA & AKT
Lactose intolerance
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Insufficient brush-border lactase → unabsorbed lactose in colon → osmotic diarrhoea (water drawn into lumen) + bacterial fermentation (H2, CO2, CH4) → bloating, flatulence, cramps
- Severity is dose-dependent - small amounts often tolerated
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