Clinical haematology · UKMLA & AKT
Patient on anti-platelet therapy
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise patient on anti-platelet therapy — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Antiphospholipid antibodies cause a paradoxically hypercoagulable state despite prolonging in-vitro clotting tests - raised APTT is a lab artefact, NOT a bleeding tendency
- Key lab pattern: raised APTT + normal PT + thrombocytopenia (NOT thrombocytosis) + APTT does not correct on mixing with normal plasma
- Clinical features: arterial thrombosis, venous thrombosis, recurrent miscarriage (≥3 consecutive or ≥1 second-trimester loss), livedo reticularis
APS causes thrombocytopenia - never thrombocytosis. Raised APTT with normal PT + recurrent miscarriage = APS until proven otherwise.
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