Dermatology · UKMLA & AKT
Psoriasis
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Chronic, immune-mediated inflammatory skin disease affecting ~2-3% of the UK population
- T-cell mediated; IL-23/IL-17 axis drives keratinocyte hyperproliferation - turnover compressed from 28 days to 3-5 days, producing parakeratosis and silvery scale
- Bimodal onset: 15-35 years and 55-60 years; strong genetic link (HLA-Cw6, ~30% have first-degree relative affected)
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