Dermatology · UKMLA & AKT
Psoriasis
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise psoriasis — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Chronic, immune-mediated inflammatory skin disease affecting ~2-3% of the UK population
- T-cell mediated; IL-23/IL-17 axis drives keratinocyte hyperproliferation - turnover compressed from 28 days to 3-5 days, producing parakeratosis and silvery scale
- Bimodal onset: 15-35 years and 55-60 years; strong genetic link (HLA-Cw6, ~30% have first-degree relative affected)
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