Endocrine & metabolic · UKMLA & AKT
Toxic multinodular goitre
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Toxic multinodular goitre (toxic MNG) is the second most common cause of hyperthyroidism after Graves' disease. Multiple thyroid nodules acquire somatic activating mutations in the TSH receptor (or Gs-alpha subunit), causing constitutive autonomous hormone secretion independent of TSH.
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