Endocrine & metabolic · UKMLA & AKT
Toxic multinodular goitre
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise toxic multinodular goitre — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Toxic multinodular goitre (toxic MNG) is the second most common cause of hyperthyroidism after Graves' disease. Multiple thyroid nodules acquire somatic activating mutations in the TSH receptor (or Gs-alpha subunit), causing constitutive autonomous hormone secretion independent of TSH.
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