Infection · UKMLA & AKT
Toxoplasmosis
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise toxoplasmosis — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Toxoplasma gondii - obligate intracellular protozoan; cat is definitive host
- Causes disease in three key groups: immunocompromised (especially HIV with CD4 <100), congenital infection, and rarely immunocompetent primary infection
- Transmission: undercooked meat (tissue cysts), cat faeces/contaminated soil (oocysts), vertical (primary maternal infection during pregnancy)
- Bradyzoites form latent tissue cysts in brain/muscle; reactivate to tachyzoites when CD4 falls
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