Infection · UKMLA & AKT
Toxoplasmosis
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Toxoplasma gondii - obligate intracellular protozoan; cat is definitive host
- Causes disease in three key groups: immunocompromised (especially HIV with CD4 <100), congenital infection, and rarely immunocompetent primary infection
- Transmission: undercooked meat (tissue cysts), cat faeces/contaminated soil (oocysts), vertical (primary maternal infection during pregnancy)
- Bradyzoites form latent tissue cysts in brain/muscle; reactivate to tachyzoites when CD4 falls
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