Clinical haematology · UKMLA & AKT
Alpha-thalassaemia
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Alpha-thalassaemia results from deletions of alpha-globin genes on chromosome 16 (normal = 4 genes, αα/αα), causing reduced alpha-chain production, microcytic hypochromic anaemia, and accumulation of abnormal haemoglobin tetramers. Most common in South-East Asian, South Asian, and African populations.
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