Clinical haematology · UKMLA & AKT

Alpha-thalassaemia

A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise alpha-thalassaemia — the full SA Note notes add investigations, management, complications and 10 practice questions.

Key high-yield points

  • Alpha-thalassaemia results from deletions of alpha-globin genes on chromosome 16 (normal = 4 genes, αα/αα), causing reduced alpha-chain production, microcytic hypochromic anaemia, and accumulation of abnormal haemoglobin tetramers. Most common in South-East Asian, South Asian, and African populations.

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Related UKMLA topics

Beta-thalassaemiaSickle cell trait and variantsIdiopathic thrombocytopenic purpura (ITP)Patient on anti-platelet therapyyeloproliferative disordersNeutropenia and neutropenic sepsis