Gastroenterology · UKMLA & AKT
Cirrhosis
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Portal hypertension → splanchnic vasodilation → perceived underfilling → RAAS activation → hyperaldosteronism → sodium retention → ascites
- Hypoalbuminaemia (reduced synthetic function) reduces oncotic pressure, worsening ascites and oedema
- Portosystemic shunting allows ammonia to bypass hepatic detoxification → hepatic encephalopathy
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