Gastroenterology · UKMLA & AKT
Cirrhosis
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise cirrhosis — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Portal hypertension → splanchnic vasodilation → perceived underfilling → RAAS activation → hyperaldosteronism → sodium retention → ascites
- Hypoalbuminaemia (reduced synthetic function) reduces oncotic pressure, worsening ascites and oedema
- Portosystemic shunting allows ammonia to bypass hepatic detoxification → hepatic encephalopathy
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