Clinical haematology · UKMLA & AKT
Follicular lymphoma
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Most common indolent lymphoma; second most common NHL overall (~20-25% of NHL)
- Median age at diagnosis ~60 years; rare under 40
- Arises from germinal centre B-cells; defined by t(14;18)(q32;q21) - brings BCL-2 under immunoglobulin heavy chain promoter → constitutive BCL-2 overexpression → block in apoptosis → accumulation of abnormal follicles
- Immunophenotype: BCL-2+, CD10+, CD20+, CD19+, BCL-6+; CD5- and CD23- (distinguishes from CLL and mantle cell lymphoma)
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