Clinical haematology · UKMLA & AKT
Follicular lymphoma
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise follicular lymphoma — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Most common indolent lymphoma; second most common NHL overall (~20-25% of NHL)
- Median age at diagnosis ~60 years; rare under 40
- Arises from germinal centre B-cells; defined by t(14;18)(q32;q21) - brings BCL-2 under immunoglobulin heavy chain promoter → constitutive BCL-2 overexpression → block in apoptosis → accumulation of abnormal follicles
- Immunophenotype: BCL-2+, CD10+, CD20+, CD19+, BCL-6+; CD5- and CD23- (distinguishes from CLL and mantle cell lymphoma)
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