Clinical haematology · UKMLA & AKT
Haemophilia A
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- X-linked recessive deficiency of factor VIII - affects ~1 in 5,000 males; ~4x more common than haemophilia B
- Factor VIII is a cofactor in the intrinsic pathway - forms tenase complex with factor IXa to amplify factor X activation; deficiency → impaired thrombin generation → fragile fibrin clot
- Primary haemostasis (platelet plug) is intact - deep bleeding occurs because the secondary fibrin clot fails
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