Clinical haematology · UKMLA & AKT

Haemophilia A

A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise haemophilia a — the full SA Note notes add investigations, management, complications and 10 practice questions.

Key high-yield points

  • X-linked recessive deficiency of factor VIII - affects ~1 in 5,000 males; ~4x more common than haemophilia B
  • Factor VIII is a cofactor in the intrinsic pathway - forms tenase complex with factor IXa to amplify factor X activation; deficiency → impaired thrombin generation → fragile fibrin clot
  • Primary haemostasis (platelet plug) is intact - deep bleeding occurs because the secondary fibrin clot fails

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Related UKMLA topics

Haemophilia BIdiopathic thrombocytopenic purpura (ITP)Patient on anti-platelet therapyyeloproliferative disordersNeutropenia and neutropenic sepsisDisseminated intravascular coagulation