Mental health · UKMLA & AKT
Mixed dementia
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise mixed dementia — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Simultaneous presence of Alzheimer's disease (AD) pathology AND cerebrovascular disease - accounts for ~10-20% of all dementia cases (likely underestimate as often only confirmed post-mortem)
- AD and vascular pathology are synergistic, not additive - amyloid impairs cerebrovascular autoregulation; ischaemia lowers threshold for amyloid to become clinically manifest → more rapid decline than either alone
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