Mental health · UKMLA & AKT

Vascular dementia

A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise vascular dementia — the full SA Note notes add investigations, management, complications and 10 practice questions.

Key high-yield points

  • Second most common cause of dementia in the UK (~15-20% of cases) after Alzheimer's disease
  • Caused by cerebrovascular disease (ischaemic or haemorrhagic injury) - white matter predominantly affected (vs cortical grey matter in Alzheimer's)
  • CADASIL - most important genetic cause; *NOTCH3* mutation, autosomal dominant, young-onset VaD with recurrent strokes and migraine with aura

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