Musculoskeletal · UKMLA & AKT
Systemic lupus erythematosus
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Chronic relapsing-remitting autoimmune disease - immune complex deposition across multiple organ systems
- Female:male ratio 9:1; peak onset 15-45 years; higher severity in Afro-Caribbean patients
- Key mechanism: defective apoptotic debris clearance → autoantibody production (anti-dsDNA, anti-Sm) → immune complex deposition → complement consumption → tissue injury
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