Musculoskeletal · UKMLA & AKT
Systemic lupus erythematosus
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise systemic lupus erythematosus — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Chronic relapsing-remitting autoimmune disease - immune complex deposition across multiple organ systems
- Female:male ratio 9:1; peak onset 15-45 years; higher severity in Afro-Caribbean patients
- Key mechanism: defective apoptotic debris clearance → autoantibody production (anti-dsDNA, anti-Sm) → immune complex deposition → complement consumption → tissue injury
Unlock the full Systemic lupus erythematosus revision
Get the complete high-yield notes (5 more sections covering investigations, management and complications), 10 practice questions, mock exams and AI tutoring. Start free.