Acute & emergency · UKMLA & AKT
Tricyclic antidepressant overdose
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- TCA overdose (e.g. amitriptyline, dosulepin, nortriptyline) causes multi-system toxicity via sodium channel blockade, antimuscarinic effects, and alpha-1 antagonism - potentially fatal even at moderate doses.
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