Acute & emergency · UKMLA & AKT
Tricyclic antidepressant overdose
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise tricyclic antidepressant overdose — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- TCA overdose (e.g. amitriptyline, dosulepin, nortriptyline) causes multi-system toxicity via sodium channel blockade, antimuscarinic effects, and alpha-1 antagonism - potentially fatal even at moderate doses.
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