Respiratory · UKMLA & AKT
Asthma COPD overlap syndrome
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise asthma copd overlap syndrome — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- ACOS = fixed post-bronchodilator airflow obstruction (FEV1/FVC <0.7) with significant bronchodilator reversibility (≥12% and ≥200 mL) and eosinophilic/asthmatic features
- Accounts for ~15-25% of obstructive airway disease; typically affects adults >40 with smoking history and background of asthma
- More exacerbations, faster FEV1 decline, and higher mortality than pure asthma or pure COPD alone
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