Respiratory · UKMLA & AKT
Asthma COPD overlap syndrome
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- ACOS = fixed post-bronchodilator airflow obstruction (FEV1/FVC <0.7) with significant bronchodilator reversibility (≥12% and ≥200 mL) and eosinophilic/asthmatic features
- Accounts for ~15-25% of obstructive airway disease; typically affects adults >40 with smoking history and background of asthma
- More exacerbations, faster FEV1 decline, and higher mortality than pure asthma or pure COPD alone
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