Respiratory · UKMLA & AKT
Cystic fibrosis
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Most common life-limiting autosomal recessive condition in the UK - 1 in 2,500 live births
- CFTR gene mutation on chromosome 7 - most common UK mutation is ΔF508
- CFTR dysfunction → reduced chloride secretion → thick viscid secretions across multiple organs
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