Respiratory · UKMLA & AKT
Cystic fibrosis
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise cystic fibrosis — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Most common life-limiting autosomal recessive condition in the UK - 1 in 2,500 live births
- CFTR gene mutation on chromosome 7 - most common UK mutation is ΔF508
- CFTR dysfunction → reduced chloride secretion → thick viscid secretions across multiple organs
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