Infection · UKMLA & AKT
Clostridioides difficile infection
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise clostridioides difficile infection — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Gram-positive, anaerobic, spore-forming bacillus - colonises large bowel when normal microbiome is disrupted by antibiotics
- Spores resist alcohol-based hand gel, heat, and acid - survive on surfaces for months
- Toxin A (enterotoxin) - fluid secretion and mucosal inflammation; Toxin B (cytotoxin) - colonocyte death and mucosal ulceration
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