Gastroenterology · UKMLA & AKT
Crohn's disease
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise crohn's disease — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Right iliac fossa pain - colicky, due to terminal ileal involvement (most common site, ~70%)
- Diarrhoea - chronic, may be nocturnal; less bloody than UC
- Weight loss and malnutrition - malabsorption, reduced intake, increased GI losses
- Perianal disease - skin tags, fissures, fistulae, abscesses
- Extra-intestinal manifestations - occur in >20%, especially with colonic disease
- Joints - peripheral arthropathy (mirrors gut activity), sacroiliitis (independent)
- Eyes - episcleritis (correlates with activity), uveitis (can be independent)
- Skin - erythema nodosum (mirrors activity), pyoderma gangrenosum (independent)
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