Gastroenterology · UKMLA & AKT
Crohn's disease
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Right iliac fossa pain - colicky, due to terminal ileal involvement (most common site, ~70%)
- Diarrhoea - chronic, may be nocturnal; less bloody than UC
- Weight loss and malnutrition - malabsorption, reduced intake, increased GI losses
- Perianal disease - skin tags, fissures, fistulae, abscesses
- Extra-intestinal manifestations - occur in >20%, especially with colonic disease
- Joints - peripheral arthropathy (mirrors gut activity), sacroiliitis (independent)
- Eyes - episcleritis (correlates with activity), uveitis (can be independent)
- Skin - erythema nodosum (mirrors activity), pyoderma gangrenosum (independent)
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