Clinical haematology · UKMLA & AKT
Hypersplenism
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Hypersplenism = overactive enlarged spleen causing excessive destruction/sequestration of blood cells, producing pancytopenia with a compensatory hyperplastic bone marrow.
The single most tested point: Howell-Jolly bodies and siderocytes on blood film = hyposplenism (e.g. coeliac disease), NOT hypersplenism. A functioning (even enlarged) spleen removes these nuclear remnants - their presence confirms splenic dysfunction or absence.
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