Clinical haematology · UKMLA & AKT
Acute leukaemia (presenting with pancytopenia)
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Acute leukaemia = unregulated clonal proliferation of immature blasts in bone marrow, displacing normal haematopoiesis → pancytopenia (anaemia, thrombocytopenia, neutropenia)
- ALL - predominantly children (peak 2-3 years); most common childhood cancer
- AML - predominantly adults (incidence rises sharply after age 60)
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