Clinical haematology · UKMLA & AKT
Acute leukaemia (presenting with pancytopenia)
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise acute leukaemia (presenting with pancytopenia) — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Acute leukaemia = unregulated clonal proliferation of immature blasts in bone marrow, displacing normal haematopoiesis → pancytopenia (anaemia, thrombocytopenia, neutropenia)
- ALL - predominantly children (peak 2-3 years); most common childhood cancer
- AML - predominantly adults (incidence rises sharply after age 60)
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