Endocrine & metabolic · UKMLA & AKT
Prolactinoma
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Dopamine from hypothalamus tonically inhibits prolactin via D2 receptors on lactotrophs - remove this brake (tumour, drug, stalk compression) and prolactin rises
- Excess prolactin suppresses GnRH → reduced LH/FSH → hypogonadotropic hypogonadism (amenorrhoea, infertility, low testosterone)
- Prolactin also acts directly on breast tissue → galactorrhoea
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