Endocrine & metabolic · UKMLA & AKT
Prolactinoma
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise prolactinoma — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Dopamine from hypothalamus tonically inhibits prolactin via D2 receptors on lactotrophs - remove this brake (tumour, drug, stalk compression) and prolactin rises
- Excess prolactin suppresses GnRH → reduced LH/FSH → hypogonadotropic hypogonadism (amenorrhoea, infertility, low testosterone)
- Prolactin also acts directly on breast tissue → galactorrhoea
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