Clinical haematology · UKMLA & AKT

Acute myeloid leukaemia (AML)

A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise acute myeloid leukaemia (aml) — the full SA Note notes add investigations, management, complications and 10 practice questions.

Key high-yield points

  • Most common acute leukaemia in adults; median age at diagnosis ~68 years
  • Malignant myeloid precursor clone - proliferates without differentiating, replacing normal marrow and causing bone marrow failure
  • Class I mutations (e.g. FLT3-ITD) drive proliferation; class II mutations (e.g. t(8;21), t(15;17)) block differentiation

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Related UKMLA topics

Chronic myeloid leukaemia (CML)Chronic lymphocytic leukaemia (CLL)Idiopathic thrombocytopenic purpura (ITP)Patient on anti-platelet therapyyeloproliferative disordersNeutropenia and neutropenic sepsis