Clinical haematology · UKMLA & AKT
Acute myeloid leukaemia (AML)
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Most common acute leukaemia in adults; median age at diagnosis ~68 years
- Malignant myeloid precursor clone - proliferates without differentiating, replacing normal marrow and causing bone marrow failure
- Class I mutations (e.g. FLT3-ITD) drive proliferation; class II mutations (e.g. t(8;21), t(15;17)) block differentiation
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