Clinical haematology · UKMLA & AKT
Chronic myeloid leukaemia (CML)
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Myeloproliferative neoplasm driven by the Philadelphia chromosome - t(9;22)(q34;q11) present in >95% of cases
- BCR-ABL1 fusion oncogene produces a constitutively active tyrosine kinase - drives uncontrolled myeloid proliferation and inhibits apoptosis
- Median age at diagnosis 55-60 years; accounts for ~15% of adult leukaemias; slight male predominance
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