Clinical haematology · UKMLA & AKT
Chronic myeloid leukaemia (CML)
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise chronic myeloid leukaemia (cml) — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Myeloproliferative neoplasm driven by the Philadelphia chromosome - t(9;22)(q34;q11) present in >95% of cases
- BCR-ABL1 fusion oncogene produces a constitutively active tyrosine kinase - drives uncontrolled myeloid proliferation and inhibits apoptosis
- Median age at diagnosis 55-60 years; accounts for ~15% of adult leukaemias; slight male predominance
Unlock the full Chronic myeloid leukaemia (CML) revision
Get the complete high-yield notes (6 more sections covering investigations, management and complications), 10 practice questions, mock exams and AI tutoring. Start free.