Endocrine & metabolic · UKMLA & AKT
Addison's disease
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Primary adrenal insufficiency caused by destruction of the adrenal cortex, impairing cortisol, aldosterone, and adrenal androgen synthesis. Most common cause in the UK is autoimmune adrenalitis (~70-80%), associated with 21-hydroxylase antibodies.
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