Endocrine & metabolic · UKMLA & AKT
Hypoglycaemia
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Counter-regulatory cascade (in order as glucose falls): insulin suppression → glucagon (glycogenolysis/gluconeogenesis) → adrenaline (glycogenolysis, lipolysis) → cortisol + growth hormone
- Brain cannot use free fatty acids as primary fuel - explains disproportionate neurological effects
- Autonomic symptoms are caused by adrenaline release - the body's alarm signal
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