Clinical haematology · UKMLA & AKT
Immune thrombocytopenia (ITP)
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- Acquired autoimmune disorder - isolated thrombocytopenia from antibody-mediated platelet destruction
- Type 2 hypersensitivity - autoreactive B cells produce IgG (anti-GPIIb/IIIa or GPIb/IX) → Fc receptor-mediated splenic phagocytosis → thrombocytopenia
- Children (age 2-10): typically follows viral illness, self-limiting (resolves in 6-12 months); adults: chronic relapsing-remitting, young women overrepresented (SLE overlap)
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