Clinical haematology · UKMLA & AKT

Immune thrombocytopenia (ITP)

A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise immune thrombocytopenia (itp) — the full SA Note notes add investigations, management, complications and 10 practice questions.

Key high-yield points

  • Acquired autoimmune disorder - isolated thrombocytopenia from antibody-mediated platelet destruction
  • Type 2 hypersensitivity - autoreactive B cells produce IgG (anti-GPIIb/IIIa or GPIb/IX) → Fc receptor-mediated splenic phagocytosis → thrombocytopenia
  • Children (age 2-10): typically follows viral illness, self-limiting (resolves in 6-12 months); adults: chronic relapsing-remitting, young women overrepresented (SLE overlap)

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Related UKMLA topics

Heparin-induced thrombocytopenia (HIT)Thrombotic thrombocytopenic purpura (TTP)Reactive thrombocytosisIdiopathic thrombocytopenic purpura (ITP)Patient on anti-platelet therapyyeloproliferative disorders