Ear, nose & throat · UKMLA & AKT
Medullary thyroid carcinoma
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise medullary thyroid carcinoma — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Accounts for ~5% of thyroid cancers
- Arises from parafollicular C-cells (not follicular cells) - produces calcitonin (key tumour marker)
- Sporadic (~75%) - solitary, unilateral, fifth to sixth decade
- Hereditary (~25%) - part of MEN 2A, MEN 2B, or familial MTC; bilateral and multifocal
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