Clinical haematology · UKMLA & AKT
Primary myelofibrosis
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise primary myelofibrosis — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Primary myelofibrosis (PMF) is the most aggressive BCR-ABL1-negative myeloproliferative neoplasm, driven by clonal haematopoietic stem cell mutations causing progressive marrow fibrosis and compensatory extramedullary haematopoiesis.
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