Endocrine & metabolic · UKMLA & AKT
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
A free high-yield preview for the UKMLA Applied Knowledge Test, covering how to recognise this condition. The full SA Note notes add investigations, management and complications, with practice questions on this topic.
Key high-yield points
- SIADH = unsuppressible ADH activity → free water retained → dilutional hyponatraemia in a euvolaemic patient. ADH binds V2 receptors on the collecting duct, inserting aquaporin-2 channels → water reabsorbed → urine concentrated, serum diluted.
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