Endocrine & metabolic · UKMLA & AKT
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise syndrome of inappropriate antidiuretic hormone secretion (siadh) — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- SIADH = unsuppressible ADH activity → free water retained → dilutional hyponatraemia in a euvolaemic patient. ADH binds V2 receptors on the collecting duct, inserting aquaporin-2 channels → water reabsorbed → urine concentrated, serum diluted.
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