Gastroenterology · UKMLA & AKT
Vitamin B12 deficiency
A free high-yield preview for the UKMLA Applied Knowledge Test. Below are the key points to recognise vitamin b12 deficiency — the full SA Note notes add investigations, management, complications and 10 practice questions.
Key high-yield points
- Dietary deficiency - strict vegans/vegetarians (B12 found only in animal products; deficiency takes years given liver stores)
- Pernicious anaemia - autoimmune atrophic gastritis causing loss of intrinsic factor; commonest cause in UK
- Post-surgical malabsorption - gastrectomy, terminal ileal resection, Roux-en-Y bypass
- Terminal ileal disease - Crohn's disease
- Drugs - metformin, PPIs, H2 antagonists, colchicine
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